By Jeff Goldberg
Announcing their findings to the clinical international thrust Hughes and Kosterlitz within the highlight and made them celebrities. quickly, scientists around the globe have been swiftly analyzing the human mind and its endorphins. In many years’ time, they might use the team’s preliminary examine to hyperlink endorphins to drug habit, runner’s excessive, urge for food keep watch over, sexual reaction, and psychological health problems resembling melancholy and schizophrenia.
In Anatomy of a systematic Discovery, Jeff Goldberg describes Hughes and Kosterlitz’s lives earlier than, in the course of, and after their historical and medical leap forward. He additionally takes a glance on the larger photo, revealing the brutal festival among drug businesses to discover the way to take advantage of this huge discovery.
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Additional info for Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine
Not because he was formulating a secret plan to look for such a substance but because he was dead set against public speculation. While the idea of an endogenous compound might be true, there was no idea of how to go about looking for it, not enough evidence to even start. Until there was firmer evidence, the idea was to be enjoyed . . ” John Hughes had not only refused to forget about it, he had begun doggedly mashing brains in search of literal proof. Kosterlitz had gone through the formality, at least, of retiring from his post as professor of clinical pharmacology in 1972 before opening his independent Unit for the Study of Addictive Drugs at Marishal.
Receptor theory was his first priority target. Goldstein’s basis for hope in an area where he was very much a newcomer rested on a technically exquisite method he had developed in the summer of 1971—a technique for testing brain soup called “grind and bind,” which became the foundation for all the future work on receptors in the field. “Grinding” consisted of decapitating about a hundred male mice and homogenizing their brains into a “soup” of cells with the consistency of a milk shake in a machine that resembled a cake mixer.
If you say such things in public,” Kosterlitz avers, “you risk making yourself foolish. ” He wrote nothing down, and he discouraged his coworkers from making any notes about such unproven theories, lest someone see them. Gordon Lees, who is currently a reader in the Aberdeen University Department of Pharmacology, also began his association with Hans Kosterlitz in the frog room. “The idea was so highly speculative that Hans was not at all keen to speak about it, except privately,” Lees recalls.