Download Amyotrophic Lateral Sclerosis: A Synthesis of Research and by Andrew Eisen, Charles Krieger PDF

By Andrew Eisen, Charles Krieger

Amyotrophic Lateral Sclerosis, in a different way referred to as Lou Gehrig's disorder, is one of many degenerative ailments of the getting older frightened approach. this article smartly synthesizes the hot explosion of analysis into this actual to build an in depth and finished assessment. Drs. Eisen and Krieger deliver their learn services and broad medical adventure to supply this useful and thought-provoking account. Chapters hide the epidemiology, molecular biology, and pathophysiology of ALS, in addition to matters pertinent to medical review and care.

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Extra resources for Amyotrophic Lateral Sclerosis: A Synthesis of Research and Clinical Practice

Example text

This has altered the geochemical environment and the soil and drinking water sufficiently to account for the dramatic change in the incidence of ALS-PD on Guam in the last two to three decades. Both the cycad toxicity theory and the role of the geochemical environment are attractive. They are not necessarily mutually exclusive, but it is difficult to conceptualize a role that is common to both. It has been speculated that the pathogenesis of Guamanian and possibly other western Pacific ALS is dependent on the interaction of one or several susceptibility genes predisposing to environmental neuronal toxicity from cycads and a deleterious geochemical environment (Roman, 1996).

Clustering of ALS A cluster of ALS has not been clearly defined but is generally considered to comprise a number of persons developing ALS who shared a restricted geographic territory, such as an apartment building, street or block. A cluster may also include individuals who have worked, for example, in the same factory, ship or football team. Such clustering of ALS has rarely been reported. A cluster of affected individuals would provide evidence for a causative environmental factor(s), but none of the cited studies has shown convincing statistical relationships.

From Zhang et al. (1996). Ada Neurologica Scandinavica, 94; 19. ) ALS-PD of Guam was the result of toxic ingestion of the cycad plant (Cycas circinalis, false sago plant) (O'Gara, Brown and Whiting, 1964). Before westernization, and with it the construction of large military bases after the Second World War and urbanization of the local island communities, 'fadan' was a staple in the Chamorro diet. This flat bread, not unlike Mexican tortilla, was prepared from the cycad nut by grinding it to a fine pulp.

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