By Cary Dicken, Marie Menke, Genevieve Neal-Perry (auth.), Nanette F. Santoro, Genevieve Neal-Perry (eds.)
Amenorrhea: A Case-Based medical advisor is a accomplished evaluation of the present wisdom concerning general woman reproductive body structure. Replete with attention-grabbing case vignettes and delivering diagnostic algorithms and healing thoughts for amenorrhea, Amenorrhea: A Case-Based scientific consultant is split into 3 sections. the 1st part consists of 2 chapters that offer an intensive overview of uncomplicated technological know-how and medical wisdom in regards to the organ structures chargeable for general body structure of the menstrual cycle. the second one part comprises dialogue approximately menstrual cycle disruption because it pertains to hypothalamic-pituitary disorder, surgical and ordinary menopause, genetic defects, untimely ovarian failure/insufficiency and the consequences of caloric extra and limit. The 3rd part deals an replace at the physiological results of lengthy amenorrhea precipitated surgically or via hypothalamic disorder and in addition comprises an unique bankruptcy that focuses exclusively at the effect of race and ethnicity at the occurrence and analysis of amenorrhea. Amenorrhea: A Case-Based scientific consultant brings jointly chapters from popular specialists who supply cutting-edge, clinically beneficial info in a case-based, reader-friendly type. This name could be a great addition to the bookshelves of all clinicians who perform in women’s healthiness settings.
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Extra resources for Amenorrhea: A Case-Based, Clinical Guide
S. Taylor receptors, thereby regulating bleeding during menstruation . Many of these agents have yet to be explored in the treatment of abnormal uterine bleeding. It is important to appreciate that prior to overt vascular breakdown and menstruation, an inflammatory process ensues and vasospasm prompts tissue degeneration. Leukocytes are recruited to the endometrium, where they make up nearly 50% of the tissue just prior to menstruation. Chemokines involved in endometrial tissue breakdown include molecules such as IL-8, which are produced by the endometrium after progesterone withdrawal.
JAMA 292:81–85 36. Du H, Taylor HS (2009) Stem cells and female reproduction. Reprod Sci 16(2):126–139 37. Dimitrov R, Timeva T, Kyurkchiev D et al (2008) Characterization of clonogenic stromal cells isolated from human endometrium. Reproduction 135:551–558 38. Du H, Taylor HS (2007) Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells 25:2082–2086 39. Mints M, Jansson M, Sadeghi B et al (2008) Endometrial endothelial cells are derived from donor stem cells in a bone marrow transplant recipient.
Of the five different variants of VEGF, VEGF 121 and 165 isoforms are the predominant forms that regulate endometrial angiogenesis. VEGF-A is produced in the glandular and luminal epithelium as well as in the stroma in the proliferative phase of the cycle. In the secretory phase of the menstrual cycle, only the epithelial cells continue to express VEGF-A [49, 50]. Several studies suggest that VEGF is hormonally regulated. Estradiol is thought to increase VEGF release; however, the exact role of ovarian hormones in the regulation of VEGF expression and function is not clear.