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By Alton Meister

Ribonuclease P: An Enzyme with a Catalytic RNA Subunit (S. Altman).

legislation of Escherichia coli Glutamine Synthetase (S. Rhee, et al.).

Glucose 6-Phosphatase: techniques of Membrane-Function dating (K. Sukalski & R. Nordlie).

Chiral Phosphorothioates: Stereochemical research of Enzymatic Substitution at Phosphorus (P. Frey).

Serotonin and Peptide Immunoneuromodulators: contemporary Discoveries and New principles (D. Silverman & M. Karnovsky).

The Phosphyglycerate Mutases (L. Fothergill-Gilmore & H. Watson).

Mechanism and law of the Glutamine-Dependent Carbamyl Phosphate Synthetase of Escherichia coli (A. Meister).

writer Index.

topic Index.

Cummulative Index, Vols.

1-62.Content:

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The isologous interaction between the two subunits of the top and bottom hexameric rings as shown in Fig. ” Additional interaction occurs between the “beta loop” from the top and bottom subunits to form a small four-stranded beta sheet. However, the heterologous interaction between neighboring subunits in the same hexameric ring is derived from side-to-side contacts between the N-domain and the C-domain of the neighboring subunits at the region of the active site channel (see Fig. 2a; the active site is where the two divalent metal ions, designated by two red spheres, bind).

Acad. Sci. USA 84, 8330 (1987). 44. , Cell 38, 219 (1984). , Science 238,527 (1987). 45. , 46. , and Altman, S . , Cell 53, 267 (1988). 47. Altman, S. , Biochemistry 25, 1205 (1986). 47a. , J . A m . Chem. 82, 1111 (1960). 48. , J . Biol. Chem. 251, 7709 (1976). 49. , J. Mol. Biol. 190, 163 (1986). 50. , Baer, M. , J . Mol. , in press. 51. , Nishikawa, S . , EMBO J. 5, 1697 (1986). 52. , personal communication. 53. , Mol. Cell. Biol. 6 , 1058 (1986). 54. , J . Biol. Chem. 260,5942 (1985). 55. S.

44. , Cell 38, 219 (1984). , Science 238,527 (1987). 45. , 46. , and Altman, S . , Cell 53, 267 (1988). 47. Altman, S. , Biochemistry 25, 1205 (1986). 47a. , J . A m . Chem. 82, 1111 (1960). 48. , J . Biol. Chem. 251, 7709 (1976). 49. , J. Mol. Biol. 190, 163 (1986). 50. , Baer, M. , J . Mol. , in press. 51. , Nishikawa, S . , EMBO J. 5, 1697 (1986). 52. , personal communication. 53. , Mol. Cell. Biol. 6 , 1058 (1986). 54. , J . Biol. Chem. 260,5942 (1985). 55. S. , Cell 44, 213 (1986). 56. , Cell 44, 225 (1986).

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